742038-81-9
742038-81-9 structure
- Name: ICA-1
- Chemical Name: ICA-1
- CAS Number: 742038-81-9
- Molecular Formula: C10H17N4O7P
- Molecular Weight: 336.241
- Create Date: 2020-01-14 18:35:06
- Modify Date: 2024-01-14 08:45:49
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ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member; potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis; significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
| Name | ICA-1 |
|---|
| Description | ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member; potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis; significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis. |
|---|---|
| References | References 1. Pillai P, et al. Int J Biochem Cell Biol. 2011 May;43(5):784-94. 2. McCray AN, et al. Neurochem Res. 2014 Sep;39(9):1691-701. 3. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17. View Related Products by Target PKC |
| Molecular Formula | C10H17N4O7P |
|---|---|
| Molecular Weight | 336.241 |