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  • DC Chemicals Limited
  • China
  • Product Name: ICA-1
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

742038-81-9

742038-81-9 structure
742038-81-9 structure
  • Name: ICA-1
  • Chemical Name: ICA-1
  • CAS Number: 742038-81-9
  • Molecular Formula: C10H17N4O7P
  • Molecular Weight: 336.241
  • Create Date: 2020-01-14 18:35:06
  • Modify Date: 2024-01-14 08:45:49
  • ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member; potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis; significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.

Name ICA-1
Description ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member; potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis; significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
References References 1. Pillai P, et al. Int J Biochem Cell Biol. 2011 May;43(5):784-94. 2. McCray AN, et al. Neurochem Res. 2014 Sep;39(9):1691-701. 3. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17. View Related Products by Target PKC
Molecular Formula C10H17N4O7P
Molecular Weight 336.241