909283-40-5
909283-40-5 structure
- Name: JTE-852
- Chemical Name: JTE-852
- CAS Number: 909283-40-5
- Molecular Formula: C23H27N5O2S
- Molecular Weight: 437.562
- Create Date: 2020-01-16 17:07:22
- Modify Date: 2024-01-12 17:10:02
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JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively; JTE-852 is less potent for Lck (IC50=80 nM), and has IC50 of >300 nM against a kinase panel screenings; inhibits the kinase activity of Syk in an intracellular condition, suppresses the secretion of histamine, LTC4/D4/E4, TXA2, PGD2, and IL-13 from mast cells stimulated by IgE-crosslinking with IC50 of 40-100 nM; attenuates IgG-mediated responses and signs in animal model of autoimmune diseases.
| Name | JTE-852 |
|---|
| Description | JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively; JTE-852 is less potent for Lck (IC50=80 nM), and has IC50 of >300 nM against a kinase panel screenings; inhibits the kinase activity of Syk in an intracellular condition, suppresses the secretion of histamine, LTC4/D4/E4, TXA2, PGD2, and IL-13 from mast cells stimulated by IgE-crosslinking with IC50 of 40-100 nM; attenuates IgG-mediated responses and signs in animal model of autoimmune diseases. |
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| References | References 1. Kato T, et al. Eur J Pharmacol. 2017 Apr 15;801:1-8. 2. Kato T, et al. Life Sci. 2017 Dec 15;191:166-174. 3. Kato T, et al. J Vet Med Sci. 2018 Jan 26. doi: 10.1292/jvms.17-0659. View Related Products by Target Syk |
| Molecular Formula | C23H27N5O2S |
|---|---|
| Molecular Weight | 437.562 |