1255303-54-8
1255303-54-8 structure
- Name: JTE-952
- Chemical Name: JTE-952
- CAS Number: 1255303-54-8
- Molecular Formula: C30H34N2O6
- Molecular Weight: 518.60
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
- Create Date: 2019-06-05 11:24:34
- Modify Date: 2024-01-10 15:05:45
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JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].
| Name | JTE-952 |
|---|
| Description | JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1]. |
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| Related Catalog | |
| Target |
IC50: 13 nM (CSF1R), 261 nM (TrkA)[1]. |
| In Vivo | JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1]. Animal Model: Mouse model of collagen-induced arthritis (CIA model)[1]. Dosage: 3 mg/kg. Administration: Oral once-daily. Result: Reduced the overall progression of the clinical score, including inflammation and bone erosion. |
| References |
| Molecular Formula | C30H34N2O6 |
|---|---|
| Molecular Weight | 518.60 |