Name | JTE-952 |
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Description | JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1]. |
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Related Catalog | |
Target |
IC50: 13 nM (CSF1R), 261 nM (TrkA)[1]. |
In Vivo | JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1]. Animal Model: Mouse model of collagen-induced arthritis (CIA model)[1]. Dosage: 3 mg/kg. Administration: Oral once-daily. Result: Reduced the overall progression of the clinical score, including inflammation and bone erosion. |
References |
Molecular Formula | C30H34N2O6 |
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Molecular Weight | 518.60 |