1131456-28-4
1131456-28-4 structure
- Name: KGP-94
- Chemical Name: KGP-94
- CAS Number: 1131456-28-4
- Molecular Formula: C14H12BrN3OS
- Molecular Weight: 350.234
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
- Create Date: 2020-01-20 18:02:56
- Modify Date: 2024-09-16 20:15:41
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KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM); significantly decreases the activity of cathepsin L toward human type I collagen, and impeds both migration and invasion of MDA-MB-231 human breast cancer cells; shows tumor growth retardation in a C3H mouse mammary carcinoma model.
| Name | KGP-94 |
|---|
| Description | KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM); significantly decreases the activity of cathepsin L toward human type I collagen, and impeds both migration and invasion of MDA-MB-231 human breast cancer cells; shows tumor growth retardation in a C3H mouse mammary carcinoma model. |
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| References | References 1. Chavarria GE, et al. Eur J Med Chem. 2012 Dec;58:568-72. 2. Parker EN, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1304-1310. 3. Sudhan DR, et al. Clin Exp Metastasis. 2013 Oct;30(7):891-902. View Related Products by Target Cathepsin |
| Molecular Formula | C14H12BrN3OS |
|---|---|
| Molecular Weight | 350.234 |