1219126-87-0
1219126-87-0 structure
- Name: OX-14
- Chemical Name: OX-14
- CAS Number: 1219126-87-0
- Molecular Formula: C9H11FN2O6P2
- Molecular Weight: 324.141
- Create Date: 2020-01-20 18:42:56
- Modify Date: 2023-01-11 18:01:43
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OX-14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite; inhibits bone resorption, significantly prevents the formation of osteolytic lesions in JJN3-NSG murine model of myeloma-induced bone disease; a new, highly potent bisphosphonate with lower bone binding affinity than other clinically relevant bisphosphonates.
| Name | OX-14 |
|---|
| Description | OX-14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite; inhibits bone resorption, significantly prevents the formation of osteolytic lesions in JJN3-NSG murine model of myeloma-induced bone disease; a new, highly potent bisphosphonate with lower bone binding affinity than other clinically relevant bisphosphonates. |
|---|---|
| References | References 1. Lawson MA, et al. J Bone Miner Res. 2017 Sep;32(9):1860-1869. View Related Products by Target Other Targets |
| Molecular Formula | C9H11FN2O6P2 |
|---|---|
| Molecular Weight | 324.141 |