1287585-40-3
1287585-40-3 structure
- Name: N-acetyl lysyltyrosylcysteine amide
- Chemical Name: N-acetyl lysyltyrosylcysteine amide
- CAS Number: 1287585-40-3
- Molecular Formula: C20H31N5O5S
- Molecular Weight: 453.56
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2020-01-11 20:56:54
- Modify Date: 2025-08-26 18:12:21
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N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL; completely inhibits HOCl production at 25 uM, decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice; reduces oxidative stress-mediated inflammation, neuronal damage, and neural stem cell injury in murine model of stroke.
| Name | N-acetyl lysyltyrosylcysteine amide |
|---|
| Description | N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL; completely inhibits HOCl production at 25 uM, decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice; reduces oxidative stress-mediated inflammation, neuronal damage, and neural stem cell injury in murine model of stroke. |
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| References | References 1. Zhang H, et al. J Lipid Res. 2013 Nov;54(11):3016-29. 2. Zhang H, et al. J Lipid Res. 2013 Nov;54(11):3009-15. 3. Yu G, et al. J Neuroinflammation. 2016 May 24;13(1):119. 4. Rymaszewski AL, et al. Cancers (Basel). 2014 May 9;6(2):1111-27. View Related Products by Target Other Targets |
| Molecular Formula | C20H31N5O5S |
|---|---|
| Molecular Weight | 453.56 |
| Hazard Codes | Xi |
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