1287585-40-3

1287585-40-3 structure

Name: N-acetyl lysyltyrosylcysteine amide
Chemical Name: N-acetyl lysyltyrosylcysteine amide
CAS Number: 1287585-40-3
Molecular Formula: C₂₀H₃₁N₅O₅S
Molecular Weight: 453.56
Catalog: Research Areas Cardiovascular Disease
Create Date: 2020-01-11 20:56:54
Modify Date: 2024-01-15 20:29:59
N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL; completely inhibits HOCl production at 25 uM, decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice; reduces oxidative stress-mediated inflammation, neuronal damage, and neural stem cell injury in murine model of stroke.

Name	N-acetyl lysyltyrosylcysteine amide

Description	N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL; completely inhibits HOCl production at 25 uM, decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice; reduces oxidative stress-mediated inflammation, neuronal damage, and neural stem cell injury in murine model of stroke.
References	References 1. Zhang H, et al. J Lipid Res. 2013 Nov;54(11):3016-29. 2. Zhang H, et al. J Lipid Res. 2013 Nov;54(11):3009-15. 3. Yu G, et al. J Neuroinflammation. 2016 May 24;13(1):119. 4. Rymaszewski AL, et al. Cancers (Basel). 2014 May 9;6(2):1111-27. View Related Products by Target Other Targets

Molecular Formula	C₂₀H₃₁N₅O₅S
Molecular Weight	453.56

Hazard Codes	Xi