1381769-23-8
1381769-23-8 structure
- Name: TC-2153
- Chemical Name: TC-2153
- CAS Number: 1381769-23-8
- Molecular Formula: C7H5ClF3NS5
- Molecular Weight: 355.869
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2020-01-15 18:51:48
- Modify Date: 2024-01-16 18:39:45
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TC-2153 is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM; increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures, shows specificity towards STEP compared to several other tyrosine phosphatases; improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels.
| Name | TC-2153 |
|---|
| Description | TC-2153 is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM; increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures, shows specificity towards STEP compared to several other tyrosine phosphatases; improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels. |
|---|---|
| References | References 1. Kulikov AV, et al. Psychopharmacology (Berl). 2012 Jun;221(3):469-78. 2. Xu J, et al. PLoS Biol. 2014 Aug 5;12(8):e1001923. 3. Baguley TD, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1044-6. 4. Chatterjee M, et al. Neuropharmacology. 2018 Jan;128:43-53. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C7H5ClF3NS5 |
|---|---|
| Molecular Weight | 355.869 |
| Symbol |
GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273-P391-P501 |
| RIDADR | UN 3077 9 / PGIII |