TC-2153

Modify Date: 2024-01-16 18:39:45

TC-2153 Structure
TC-2153 structure
Common Name TC-2153
CAS Number 1381769-23-8 Molecular Weight 355.869
Density N/A Boiling Point N/A
Molecular Formula C7H5ClF3NS5 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS09
GHS09
Signal Word Warning

 Use of TC-2153


TC-2153 is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM; increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures, shows specificity towards STEP compared to several other tyrosine phosphatases; improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels.

 Names

Name TC-2153

 TC-2153 Biological Activity

Description TC-2153 is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM; increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures, shows specificity towards STEP compared to several other tyrosine phosphatases; improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels.
References References 1. Kulikov AV, et al. Psychopharmacology (Berl). 2012 Jun;221(3):469-78. 2. Xu J, et al. PLoS Biol. 2014 Aug 5;12(8):e1001923. 3. Baguley TD, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1044-6. 4. Chatterjee M, et al. Neuropharmacology. 2018 Jan;128:43-53. View Related Products by Target Protein Phosphatase/PTP

 Chemical & Physical Properties

Molecular Formula C7H5ClF3NS5
Molecular Weight 355.869

 Safety Information

Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P391-P501
RIDADR UN 3077 9 / PGIII
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