1427304-84-4
1427304-84-4 structure
- Name: NBD-11021
- Chemical Name: NBD-11021
- CAS Number: 1427304-84-4
- Molecular Formula: C22H25ClN4O2S
- Molecular Weight: 444.978
- Create Date: 2020-01-20 13:32:57
- Modify Date: 2024-04-06 08:23:00
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A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM). HIV Preclinical
| Name | NBD-11021 |
|---|
| Description | A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM). HIV Preclinical |
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| References | References 1. Curreli F, et al. J Med Chem. 2015 Sep 10;58(17):6909-6927. View Related Products by Target HIV HIV |
| Molecular Formula | C22H25ClN4O2S |
|---|---|
| Molecular Weight | 444.978 |