1446350-60-2
1446350-60-2 structure
- Name: TCH-165
- Chemical Name: TCH-165
- CAS Number: 1446350-60-2
- Molecular Formula: C39H37N3O3
- Molecular Weight: 595.743
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2020-01-12 07:30:49
- Modify Date: 2025-08-25 14:06:03
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TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation; enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture; display a decrease in assembled 26S and an increase in 20S proteasome in treated cells.
| Name | TCH-165 |
|---|
| Description | TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation; enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture; display a decrease in assembled 26S and an increase in 20S proteasome in treated cells. |
|---|---|
| References | References 1. Njomen E, et al. Biochemistry. 2018 Jul 17;57(28):4214-4224. 2. Azevedo LM, et al. J Med Chem. 2013 Jul 25;56(14):5974-8. View Related Products by Target Proteasome |
| Molecular Formula | C39H37N3O3 |
|---|---|
| Molecular Weight | 595.743 |