1446350-60-2

1446350-60-2 structure

Name: TCH-165
Chemical Name: TCH-165
CAS Number: 1446350-60-2
Molecular Formula: C₃₉H₃₇N₃O₃
Molecular Weight: 595.743
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2020-01-12 07:30:49
Modify Date: 2024-01-11 19:40:54
TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation; enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture; display a decrease in assembled 26S and an increase in 20S proteasome in treated cells.

Name	TCH-165

Description	TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation; enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture; display a decrease in assembled 26S and an increase in 20S proteasome in treated cells.
References	References 1. Njomen E, et al. Biochemistry. 2018 Jul 17;57(28):4214-4224. 2. Azevedo LM, et al. J Med Chem. 2013 Jul 25;56(14):5974-8. View Related Products by Target Proteasome

Molecular Formula	C₃₉H₃₇N₃O₃
Molecular Weight	595.743