TCH-165
Modify Date: 2025-08-25 14:06:03
TCH-165 structure
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Common Name | TCH-165 | ||
|---|---|---|---|---|
| CAS Number | 1446350-60-2 | Molecular Weight | 595.743 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H37N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TCH-165TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation; enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture; display a decrease in assembled 26S and an increase in 20S proteasome in treated cells. |
| Name | TCH-165 |
|---|
| Description | TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation; enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture; display a decrease in assembled 26S and an increase in 20S proteasome in treated cells. |
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| References | References 1. Njomen E, et al. Biochemistry. 2018 Jul 17;57(28):4214-4224. 2. Azevedo LM, et al. J Med Chem. 2013 Jul 25;56(14):5974-8. View Related Products by Target Proteasome |
| Molecular Formula | C39H37N3O3 |
|---|---|
| Molecular Weight | 595.743 |