1565845-92-2
1565845-92-2 structure
- Name: 1E7-03
- Chemical Name: 1E7-03
- CAS Number: 1565845-92-2
- Molecular Formula: C28H29N3O6
- Molecular Weight: 503.555
- Create Date: 2020-01-11 18:59:49
- Modify Date: 2024-04-09 14:55:20
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1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM); disrupts the interaction of Tat with PP1, inhibits HIV-1 transcription with IC50 of 2 uM, with no cytotoxicity and displays a plasma half-life greater than 8 h in mice; inhibits EBOV transcription and strongly induces VP30 phosphorylation in the N-terminal Ser residues 29-46.
| Name | 1E7-03 |
|---|
| Description | 1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM); disrupts the interaction of Tat with PP1, inhibits HIV-1 transcription with IC50 of 2 uM, with no cytotoxicity and displays a plasma half-life greater than 8 h in mice; inhibits EBOV transcription and strongly induces VP30 phosphorylation in the N-terminal Ser residues 29-46. |
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| References | References 1. Carey BD, et al. J Virol. 2018 May 16. pii: JVI.02068-17. 2. Ilinykh PA, et al. J Biol Chem. 2014 Aug 15;289(33):22723-38. 3. Ammosova T, et al. Br J Pharmacol. 2014 Nov;171(22):5059-75. 4. Lin X, et al. Oncotarget. 2017 Aug 7;8(44):76749-76769. View Related Products by Target HIV |
| Molecular Formula | C28H29N3O6 |
|---|---|
| Molecular Weight | 503.555 |