1E7-03
Modify Date: 2024-04-09 14:55:20
1E7-03 structure
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Common Name | 1E7-03 | ||
|---|---|---|---|---|
| CAS Number | 1565845-92-2 | Molecular Weight | 503.555 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H29N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 1E7-031E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM); disrupts the interaction of Tat with PP1, inhibits HIV-1 transcription with IC50 of 2 uM, with no cytotoxicity and displays a plasma half-life greater than 8 h in mice; inhibits EBOV transcription and strongly induces VP30 phosphorylation in the N-terminal Ser residues 29-46. |
| Name | 1E7-03 |
|---|
| Description | 1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM); disrupts the interaction of Tat with PP1, inhibits HIV-1 transcription with IC50 of 2 uM, with no cytotoxicity and displays a plasma half-life greater than 8 h in mice; inhibits EBOV transcription and strongly induces VP30 phosphorylation in the N-terminal Ser residues 29-46. |
|---|---|
| References | References 1. Carey BD, et al. J Virol. 2018 May 16. pii: JVI.02068-17. 2. Ilinykh PA, et al. J Biol Chem. 2014 Aug 15;289(33):22723-38. 3. Ammosova T, et al. Br J Pharmacol. 2014 Nov;171(22):5059-75. 4. Lin X, et al. Oncotarget. 2017 Aug 7;8(44):76749-76769. View Related Products by Target HIV |
| Molecular Formula | C28H29N3O6 |
|---|---|
| Molecular Weight | 503.555 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 1E7-03
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: 1E7-03
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: 1E7-03
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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