1616359-00-2
1616359-00-2 structure
- Name: SEL24-B489
- Chemical Name: SEL24-B489
- CAS Number: 1616359-00-2
- Molecular Formula: C15H18Br2N4O2
- Molecular Weight: 446.143
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-20 12:28:55
- Modify Date: 2024-11-21 11:45:15
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SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively; exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors, decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors; inhibits the growth of a broad panel of AML cell lines in xenograft models. Blood Cancer Phase 2 Clinical
| Name | SEL24-B489 |
|---|
| Description | SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively; exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors, decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors; inhibits the growth of a broad panel of AML cell lines in xenograft models. Blood Cancer Phase 2 Clinical |
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| References | References 1. Czardybon W, et al. Oncotarget. 2018 Mar 30;9(24):16917-16931. 2. Białopiotrowicz E, et al. J Cell Mol Med. 2018 Apr 17. doi: 10.1111/jcmm.13632. 3. Szydłowski M, et al. Blood. 2017 Sep 21;130(12):1418-1429. View Related Products by Target Pim Blood Cancer |
| Molecular Formula | C15H18Br2N4O2 |
|---|---|
| Molecular Weight | 446.143 |