1620746-09-9
1620746-09-9 structure
- Name: SHP2 inhibitor 11a-1
- Chemical Name: SHP2 inhibitor 11a-1
- CAS Number: 1620746-09-9
- Molecular Formula: C28H20IN3O5S
- Molecular Weight: 637.448
- Create Date: 2020-01-12 13:59:50
- Modify Date: 2024-07-24 16:07:42
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A potent, selective, cell active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs; specifically attenuates the SHP2-dependent signaling in cell; blocks growth factor mediated Erk1/2 and Akt activation and exhibits excellent antiproliferative activity in lung cancer and breast cancer as well as leukemia cell lines; ameliorates the pathogenesis of systemic lupus erythematosus in mice.
| Name | SHP2 inhibitor 11a-1 |
|---|
| Description | A potent, selective, cell active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs; specifically attenuates the SHP2-dependent signaling in cell; blocks growth factor mediated Erk1/2 and Akt activation and exhibits excellent antiproliferative activity in lung cancer and breast cancer as well as leukemia cell lines; ameliorates the pathogenesis of systemic lupus erythematosus in mice. |
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| References | References 1. Zeng LF, et al. J Med Chem. 2014 Aug 14;57(15):6594-609. 2. Wang J, et al. J Clin Invest. 2016 Jun 1;126(6):2077-92. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C28H20IN3O5S |
|---|---|
| Molecular Weight | 637.448 |