1800285-51-1
1800285-51-1 structure
- Name: HS-72
- Chemical Name: HS-72
- CAS Number: 1800285-51-1
- Molecular Formula: C20H24N6O
- Molecular Weight: 364.44
- Create Date: 2020-01-20 18:41:56
- Modify Date: 2023-01-25 02:28:07
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HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome; inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines; causes degradation of HER2 and Akt; is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity.
| Name | HS-72 |
|---|
| Description | HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome; inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines; causes degradation of HER2 and Akt; is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity. |
|---|---|
| References | References 1. Howe MK, et al. Chem Biol. 2014 Dec 18;21(12):1648-59. 2. Howe MK, et al. Antiviral Res. 2016 Jun;130:81-92. View Related Products by Target Heat Shock Protein (HSP) |
| Molecular Formula | C20H24N6O |
|---|---|
| Molecular Weight | 364.44 |