1802158-63-9
1802158-63-9 structure
- Name: MT-031
- Chemical Name: MT-031
- CAS Number: 1802158-63-9
- Molecular Formula: C16H22N2O2
- Molecular Weight: 274.364
- Create Date: 2020-01-12 12:13:49
- Modify Date: 2024-01-03 10:23:39
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A potent, brain penetrant, dual MAO-A and AChE inhibitor that shows neuroprotective effects both in vitro and in vivo; inhibits H2O2-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, and antagonizes scopolamine-induced memory and cognitive impairments in mice; upregulates mRNA expression levels of Bcl-2, the neurotrophic factors and the anti-inflammatory cytokine, Ntrk, and down-regulates the mRNA expression levels of IL-6 in scopolamine-induced mice.
| Name | MT-031 |
|---|
| Description | A potent, brain penetrant, dual MAO-A and AChE inhibitor that shows neuroprotective effects both in vitro and in vivo; inhibits H2O2-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, and antagonizes scopolamine-induced memory and cognitive impairments in mice; upregulates mRNA expression levels of Bcl-2, the neurotrophic factors and the anti-inflammatory cytokine, Ntrk, and down-regulates the mRNA expression levels of IL-6 in scopolamine-induced mice. |
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| References | References 1. Liu W, et al. Neuropharmacology. 2017 Feb;113(Pt A):445-456. 2. Liu W, et al. Neuropharmacology. 2016 Oct;109:376-385. View Related Products by Target Monoamine Oxidase (MAO) |
| Molecular Formula | C16H22N2O2 |
|---|---|
| Molecular Weight | 274.364 |