18360-29-7

18360-29-7 structure

Name: AD 2900
Chemical Name: AD 2900
CAS Number: 18360-29-7
Molecular Formula: C₂₀H₄₃NO₃
Molecular Weight: 345.568
Create Date: 2020-01-13 01:40:21
Modify Date: 2024-07-22 10:02:52
AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively; shows no significant agonism effects (EC50>50 uM); suppresses PBMC proliferation, regulates the expression of S1P1 and CCR7 on PBMCs; accumulates T cells in the blood and spleen and in turn reduces T-cell number in the lymph nodes, shows significant effects on the localization of T-cell subpopulations in mice.

Name	AD 2900

Description	AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively; shows no significant agonism effects (EC50>50 uM); suppresses PBMC proliferation, regulates the expression of S1P1 and CCR7 on PBMCs; accumulates T cells in the blood and spleen and in turn reduces T-cell number in the lymph nodes, shows significant effects on the localization of T-cell subpopulations in mice.
References	References 1. Song J, et al. Oncotarget. 2017 Jun 27;8(32):53563-53580. 2. Dagan A, et al. Biochim Biophys Acta. 2003 Sep 22;1633(3):161-9. View Related Products by Target Lysophospholipid Receptor

Molecular Formula	C₂₀H₄₃NO₃
Molecular Weight	345.568