1845726-14-8
1845726-14-8 structure
- Name: CPI 0610
- Chemical Name: CPI 0610
- CAS Number: 1845726-14-8
- Molecular Formula: C20H16ClN3O2
- Molecular Weight: 365.817
- Create Date: 2020-01-11 19:03:50
- Modify Date: 2024-01-14 21:11:20
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CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay; shows remarkably selectivity, over the bromodomains of CBP, BRD9, BRPF1, PCAF, BRG1, ATAD2, TRIM24, BRD8; has an IC50 of 0.18 uM in MYC RNA expression assay; demonstrates antitumor efficacy in an MV-4-11 mouse xenograft model.
| Name | CPI 0610 |
|---|
| Description | CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay; shows remarkably selectivity, over the bromodomains of CBP, BRD9, BRPF1, PCAF, BRG1, ATAD2, TRIM24, BRD8; has an IC50 of 0.18 uM in MYC RNA expression assay; demonstrates antitumor efficacy in an MV-4-11 mouse xenograft model. |
|---|---|
| References | References 1. Albrecht BK, et al. J Med Chem. 2016 Feb 25;59(4):1330-9. 2. Siu KT, et al. Leukemia. 2017 Jan 3. doi: 10.1038/leu.2016.355. View Related Products by Target Bromodomain |
| Molecular Formula | C20H16ClN3O2 |
|---|---|
| Molecular Weight | 365.817 |