Name | SirReal2 |
---|
Description | SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1. |
---|---|
References | References 1. Rumpf T, et al. Nat Commun. 2015 Feb 12;6:6263. 2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. View Related Products by Target Sirtuin |
Molecular Formula | C22H20N4OS2 |
---|---|
Molecular Weight | 420.549 |