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1884231-52-0

1884231-52-0 structure
1884231-52-0 structure
  • Name: HDAC8-IN-20a
  • Chemical Name: HDAC8-IN-20a
  • CAS Number: 1884231-52-0
  • Molecular Formula: C15H15NO4
  • Molecular Weight: 273.288
  • Create Date: 2020-01-11 20:32:51
  • Modify Date: 2024-04-09 19:21:16
  • HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM; efficiently blocks the activation of growth receptor survival signaling and shifts the cell cycle arrest and differentiation phenotype toward effective cell death of neuroblastoma cell lines combined with crizotinib, efficiently kills neuroblastoma cell lines carrying wildtype ALK, amplified ALK and those carrying the activating ALK F1174L mutation, as well as cells carrying the activating R1275Q mutation.

Name HDAC8-IN-20a
Description HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM; efficiently blocks the activation of growth receptor survival signaling and shifts the cell cycle arrest and differentiation phenotype toward effective cell death of neuroblastoma cell lines combined with crizotinib, efficiently kills neuroblastoma cell lines carrying wildtype ALK, amplified ALK and those carrying the activating ALK F1174L mutation, as well as cells carrying the activating R1275Q mutation.
References References 1. Heimburg T, et al. J Med Chem. 2017 Dec 15. doi: 10.1021/acs.jmedchem.7b01447. 2. Shen J, et al. Cell Death Differ. 2018 Mar 7. doi: 10.1038/s41418-018-0080-0. View Related Products by Target HDAC
Molecular Formula C15H15NO4
Molecular Weight 273.288