189498-57-5
189498-57-5 structure
- Name: ABT-080
- Chemical Name: ABT-080
- CAS Number: 189498-57-5
- Molecular Formula: C37H31N2NaO4
- Molecular Weight: 590.655
- Create Date: 2020-01-12 11:23:49
- Modify Date: 2022-01-27 23:58:49
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ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM; selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing; demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model. Asthma Discontinued
| Name | ABT-080 |
|---|
| Description | ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM; selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing; demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model. Asthma Discontinued |
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| References | References 1. Kolasa T, et al. J Med Chem. 2000 Aug 24;43(17):3322-34. View Related Products by Target FLAP Asthma |
| Molecular Formula | C37H31N2NaO4 |
|---|---|
| Molecular Weight | 590.655 |