1926989-06-1
1926989-06-1 structure
- Name: GNE-375
- Chemical Name: GNE-375
- CAS Number: 1926989-06-1
- Molecular Formula: C25H29N3O5
- Molecular Weight: 451.523
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2020-01-20 10:58:56
- Modify Date: 2025-08-24 16:19:58
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GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1; decreases BRD9 binding to chromatin, and decreases expression of ALDH1A1, a gene previously shown to be important in drug tolerance; shows remarkable potency in preventing the emergence of a drug tolerant population in EGFR mutant PC9 cells treated with EGFR inhibitors.
| Name | GNE-375 |
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| Description | GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1; decreases BRD9 binding to chromatin, and decreases expression of ALDH1A1, a gene previously shown to be important in drug tolerance; shows remarkable potency in preventing the emergence of a drug tolerant population in EGFR mutant PC9 cells treated with EGFR inhibitors. |
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| References | References 1. Crawford TD, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541. View Related Products by Target Bromodomain |
| Molecular Formula | C25H29N3O5 |
|---|---|
| Molecular Weight | 451.523 |