GNE-375
Modify Date: 2024-10-04 14:00:05
GNE-375 structure
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Common Name | GNE-375 | ||
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| CAS Number | 1926989-06-1 | Molecular Weight | 451.523 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H29N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE-375GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1; decreases BRD9 binding to chromatin, and decreases expression of ALDH1A1, a gene previously shown to be important in drug tolerance; shows remarkable potency in preventing the emergence of a drug tolerant population in EGFR mutant PC9 cells treated with EGFR inhibitors. |
| Name | GNE-375 |
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| Description | GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1; decreases BRD9 binding to chromatin, and decreases expression of ALDH1A1, a gene previously shown to be important in drug tolerance; shows remarkable potency in preventing the emergence of a drug tolerant population in EGFR mutant PC9 cells treated with EGFR inhibitors. |
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| References | References 1. Crawford TD, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541. View Related Products by Target Bromodomain |
| Molecular Formula | C25H29N3O5 |
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| Molecular Weight | 451.523 |