193282-45-0
193282-45-0 structure
- Name: RWJ-49815
- Chemical Name: RWJ-49815
- CAS Number: 193282-45-0
- Molecular Formula: C30H31N3O
- Molecular Weight: 449.598
- Create Date: 2020-01-11 20:36:51
- Modify Date: 2024-01-28 00:31:46
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A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin.
| Name | RWJ-49815 |
|---|
| Description | A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin. |
|---|---|
| References | References 1. Barrett JF, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22. 2. Stephenson K, et al. J Biol Chem. 2000 Dec 8;275(49):38900-4. 3. Theodorou EC, et al. Cell Signal. 2011 Aug;23(8):1327-37. View Related Products by Target Bacterial |
| Molecular Formula | C30H31N3O |
|---|---|
| Molecular Weight | 449.598 |