162112-37-0

162112-37-0 structure

Name: RWJ 50271
Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-{4-[3-(trifluoromethyl)phenyl]-1,3 -thiazol-2-yl}-1H-pyrazole-4-carboxamide
CAS Number: 162112-37-0
Molecular Formula: C₁₈H₁₇F₃N₄O₂S
Molecular Weight: 410.41
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2017-06-10 02:12:25
Modify Date: 2024-01-16 13:43:03
RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].

Name	N-(3-Hydroxypropyl)-5-methyl-1-{4-[3-(trifluoromethyl)phenyl]-1,3 -thiazol-2-yl}-1H-pyrazole-4-carboxamide

Description	RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Cytoskeleton >> Integrin
Target	IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells)[1]
References	[1]. Sanfilippo PJ, et al. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J Med Chem. 1995 Mar 31;38(7):1057-9.