1957276-35-5
1957276-35-5 structure
- Name: SHP836
- Chemical Name: SHP836
- CAS Number: 1957276-35-5
- Molecular Formula: C16H19Cl2N5
- Molecular Weight: 352.263
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2020-01-20 11:06:57
- Modify Date: 2024-01-14 17:34:54
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SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells; enhances pharmacological pathway inhibition in cells combined with SHP099.
| Name | SHP836 |
|---|
| Description | SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells; enhances pharmacological pathway inhibition in cells combined with SHP099. |
|---|---|
| References | References 1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C16H19Cl2N5 |
|---|---|
| Molecular Weight | 352.263 |
| Hazard Codes | Xi |
|---|