2095172-11-3
2095172-11-3 structure
- Name: RET-IN-23c
- Chemical Name: RET-IN-23c
- CAS Number: 2095172-11-3
- Molecular Formula: C13H16N6O2
- Molecular Weight: 288.311
- Create Date: 2020-01-20 19:18:56
- Modify Date: 2024-09-16 16:41:37
-
RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR; inhibits the phosphorylation of RET and the phosphorylation of STAT3 and AKT; exhibits antiproliferative effects against BaF3/CCDC6-RET cells with IC50 of 433 nM.
| Name | RET-IN-23c |
|---|
| Description | RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR; inhibits the phosphorylation of RET and the phosphorylation of STAT3 and AKT; exhibits antiproliferative effects against BaF3/CCDC6-RET cells with IC50 of 433 nM. |
|---|---|
| References | References 1. Wang C, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2544-2548. View Related Products by Target RET Tyrosine Kinase (c-RET) |
| Molecular Formula | C13H16N6O2 |
|---|---|
| Molecular Weight | 288.311 |