2096992-20-8
2096992-20-8 structure
- Name: NVP-MELK8a hydrochloride
- Chemical Name: NVP-MELK8a hydrochloride
- CAS Number: 2096992-20-8
- Molecular Formula: C25H33ClN6O
- Molecular Weight: 469.02212
- Create Date: 2020-01-12 10:33:51
- Modify Date: 2024-04-03 00:25:25
-
NVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM; exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM); exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content.
| Name | NVP-MELK8a hydrochloride |
|---|
| Description | NVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM; exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM); exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content. |
|---|---|
| References | References 1. Touré BB, et al. J Med Chem. 2016 May 26;59(10):4711-23. 2. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693. View Related Products by Target MELK |
| Molecular Formula | C25H33ClN6O |
|---|---|
| Molecular Weight | 469.02212 |
| Storage condition | 2-8℃ |