2165322-95-0
2165322-95-0 structure
- Name: USP25 and 28 inhibitor AZ-2
- Chemical Name: USP25 and 28 inhibitor AZ-2
- CAS Number: 2165322-95-0
- Molecular Formula: C17H17BrF3NO3
- Molecular Weight: 420.226
- Create Date: 2020-01-11 15:27:54
- Modify Date: 2024-01-09 07:11:29
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USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
| Name | USP25 and 28 inhibitor AZ-2 |
|---|
| Description | USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines. |
|---|---|
| References | References 1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334. View Related Products by Target Deubiquitinase (DUB) |
| Molecular Formula | C17H17BrF3NO3 |
|---|---|
| Molecular Weight | 420.226 |