2204270-73-3
2204270-73-3 structure
- Name: MY10
- Chemical Name: MY10
- CAS Number: 2204270-73-3
- Molecular Formula: C15H10F6OS2
- Molecular Weight: 384.354
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2020-01-12 11:07:50
- Modify Date: 2024-04-04 21:02:31
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MY10 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation; blocks ethanol conditioned place preference, shows limited effects on ethanol-induced ataxia, and potentiates the sedative effects of ethanol in mice; increases levels of phosphorylated ALK and TrkA in neuroblastoma cells, modulates signaling pathways activated by alcohol.
| Name | MY10 |
|---|
| Description | MY10 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation; blocks ethanol conditioned place preference, shows limited effects on ethanol-induced ataxia, and potentiates the sedative effects of ethanol in mice; increases levels of phosphorylated ALK and TrkA in neuroblastoma cells, modulates signaling pathways activated by alcohol. |
|---|---|
| References | References 1. Fernández-Calle R, et al. Neuropharmacology. 2018 May 9;137:86-95. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C15H10F6OS2 |
|---|---|
| Molecular Weight | 384.354 |