2230640-94-3
2230640-94-3 structure
- Name: TT-10
- Chemical Name: TT-10
- CAS Number: 2230640-94-3
- Molecular Formula: C11H10FN3OS2
- Molecular Weight: 283.339
- Catalog: Signaling Pathways Stem Cell/Wnt YAP
- Create Date: 2020-01-19 17:30:27
- Modify Date: 2024-01-04 07:02:52
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TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes; promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway; ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice.
| Name | TT-10 |
|---|
| Description | TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes; promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway; ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice. |
|---|---|
| References | References 1. Hara H, et al. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. View Related Products by Target Yes-associated Protein (YAP) |
| Molecular Formula | C11H10FN3OS2 |
|---|---|
| Molecular Weight | 283.339 |