TT-10
Modify Date: 2025-08-21 20:53:46
TT-10 structure
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Common Name | TT-10 | ||
|---|---|---|---|---|
| CAS Number | 2230640-94-3 | Molecular Weight | 283.339 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H10FN3OS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TT-10TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes; promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway; ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice. |
| Name | TT-10 |
|---|
| Description | TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes; promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway; ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice. |
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| References | References 1. Hara H, et al. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. View Related Products by Target Yes-associated Protein (YAP) |
| Molecular Formula | C11H10FN3OS2 |
|---|---|
| Molecular Weight | 283.339 |
| InChIKey | GVYPHJQPOHDZEI-UHFFFAOYSA-N |
| SMILES | C=CCNc1nc(N)c(C(=O)c2ccc(F)s2)s1 |