292168-90-2
292168-90-2 structure
- Name: IT-603
- Chemical Name: IT-603
- CAS Number: 292168-90-2
- Molecular Formula: C11H9BrN2O3S
- Molecular Weight: 329.168
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2020-01-11 18:16:50
- Modify Date: 2024-01-04 11:12:10
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A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity.
| Name | IT-603 |
|---|
| Description | A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity. |
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| References | References 1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91. View Related Products by Target NF-κB |
| Molecular Formula | C11H9BrN2O3S |
|---|---|
| Molecular Weight | 329.168 |