487001-04-7
487001-04-7 structure
- Name: UC-857993
- Chemical Name: UC-857993
- CAS Number: 487001-04-7
- Molecular Formula: C25H22ClNO2
- Molecular Weight: 403.906
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2020-01-20 19:09:57
- Modify Date: 2024-01-21 14:47:45
-
A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells.
| Name | UC-857993 |
|---|
| Description | A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells. |
|---|---|
| References | References 1. Evelyn CR, et al. J Biol Chem. 2015 May 15;290(20):12879-98. View Related Products by Target Ras |
| Molecular Formula | C25H22ClNO2 |
|---|---|
| Molecular Weight | 403.906 |