UC-857993
Modify Date: 2025-09-11 09:58:53
UC-857993 structure
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Common Name | UC-857993 | ||
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| CAS Number | 487001-04-7 | Molecular Weight | 403.906 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H22ClNO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UC-857993A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells. |
| Name | UC-857993 |
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| Description | A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells. |
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| References | References 1. Evelyn CR, et al. J Biol Chem. 2015 May 15;290(20):12879-98. View Related Products by Target Ras |
| Molecular Formula | C25H22ClNO2 |
|---|---|
| Molecular Weight | 403.906 |
| InChIKey | RKRFFBBVYHOUSA-UHFFFAOYSA-N |
| SMILES | O=C(O)c1cc2c3c(c1)C1C=CCC1C(c1ccccc1Cl)N3CC1CC=CC21 |