628298-68-0
628298-68-0 structure
- Name: DD-01050
- Chemical Name: DD-01050
- CAS Number: 628298-68-0
- Molecular Formula: C26H33Cl4N7O3
- Molecular Weight: 633.396
- Create Date: 2020-01-12 06:47:51
- Modify Date: 2024-03-28 11:35:12
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A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity; preferentially inhibits TRPV1, showing marginal block of other neuronal receptors; inhibits capsaicin-evoked nerve activity in afferent fibers without affecting mechanically activated activity, attenuates carrageenan-induced paw inflammation, without affecting normal nociception in vivo; also decreases the cells in S/G2/M phases in prostate PC3 cells.
| Name | DD-01050 |
|---|
| Description | A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity; preferentially inhibits TRPV1, showing marginal block of other neuronal receptors; inhibits capsaicin-evoked nerve activity in afferent fibers without affecting mechanically activated activity, attenuates carrageenan-induced paw inflammation, without affecting normal nociception in vivo; also decreases the cells in S/G2/M phases in prostate PC3 cells. |
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| References | References 1. García-Martínez C, et al. J Pain. 2006 Oct;7(10):735-46. 2. Valero ML, et al. PLoS One. 2012;7(12):e51825. View Related Products by Target TRP Channel |
| Molecular Formula | C26H33Cl4N7O3 |
|---|---|
| Molecular Weight | 633.396 |