681282-09-7
681282-09-7 structure
- Name: MYCMI-6(NSC 354961)
- Chemical Name: MYCMI-6
- CAS Number: 681282-09-7
- Molecular Formula: C20H19N7O
- Molecular Weight: 373.42
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-20 12:07:56
- Modify Date: 2024-09-16 09:47:27
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MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay; specifcally targets MYC:MAX interaction without interfering with other MYC activities, selectively suppresses MYC-driven tumor cell growth with high efficacy, efficiently inhibits anchorage-independent growth of MYCN-amplifed neuroblastoma cells with GI50 values of <0.4, 5 and 0.75 μM, respectively; reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects
| Name | MYCMI-6 |
|---|
| Description | MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay; specifcally targets MYC:MAX interaction without interfering with other MYC activities, selectively suppresses MYC-driven tumor cell growth with high efficacy, efficiently inhibits anchorage-independent growth of MYCN-amplifed neuroblastoma cells with GI50 values of <0.4, 5 and 0.75 μM, respectively; reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects |
|---|---|
| References | References 1. Castell A, et al. Sci Rep. 2018 Jul 3;8(1):10064. View Related Products by Target c-Myc |
| Molecular Formula | C20H19N7O |
|---|---|
| Molecular Weight | 373.42 |
| Hazard Codes | Xi |
|---|