80261-18-3
80261-18-3 structure
- Name: GTC 365
- Chemical Name: GTC 365
- CAS Number: 80261-18-3
- Molecular Formula: C23H23N7O4S
- Molecular Weight: 493.542
- Create Date: 2020-01-20 16:18:56
- Modify Date: 2024-05-06 09:51:02
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GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters; acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstates the correct folding pathway, and reduces hTERT activity through transcriptional repression; binds to WT and G124/125A telomeric G-quadruplexes with a similar binding affinity (Kd=400 nM).
| Name | GTC 365 |
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| Description | GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters; acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstates the correct folding pathway, and reduces hTERT activity through transcriptional repression; binds to WT and G124/125A telomeric G-quadruplexes with a similar binding affinity (Kd=400 nM). |
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| References | References 1. Kang HJ, et al. J. Am. Chem. Soc., 2016, 138 (41), pp 13673–13692 View Related Products by Target Telomerase |
| Molecular Formula | C23H23N7O4S |
|---|---|
| Molecular Weight | 493.542 |