80261-18-3

80261-18-3 structure

Name: GTC 365
Chemical Name: GTC 365
CAS Number: 80261-18-3
Molecular Formula: C₂₃H₂₃N₇O₄S
Molecular Weight: 493.542
Create Date: 2020-01-20 16:18:56
Modify Date: 2024-05-06 09:51:02
GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters; acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstates the correct folding pathway, and reduces hTERT activity through transcriptional repression; binds to WT and G124/125A telomeric G-quadruplexes with a similar binding affinity (Kd=400 nM).

Name	GTC 365

Description	GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters; acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstates the correct folding pathway, and reduces hTERT activity through transcriptional repression; binds to WT and G124/125A telomeric G-quadruplexes with a similar binding affinity (Kd=400 nM).
References	References 1. Kang HJ, et al. J. Am. Chem. Soc., 2016, 138 (41), pp 13673–13692 View Related Products by Target Telomerase

Molecular Formula	C₂₃H₂₃N₇O₄S
Molecular Weight	493.542