GTC 365
Modify Date: 2024-05-06 09:51:02
GTC 365 structure
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Common Name | GTC 365 | ||
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| CAS Number | 80261-18-3 | Molecular Weight | 493.542 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23N7O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GTC 365GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters; acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstates the correct folding pathway, and reduces hTERT activity through transcriptional repression; binds to WT and G124/125A telomeric G-quadruplexes with a similar binding affinity (Kd=400 nM). |
| Name | GTC 365 |
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| Description | GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters; acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstates the correct folding pathway, and reduces hTERT activity through transcriptional repression; binds to WT and G124/125A telomeric G-quadruplexes with a similar binding affinity (Kd=400 nM). |
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| References | References 1. Kang HJ, et al. J. Am. Chem. Soc., 2016, 138 (41), pp 13673–13692 View Related Products by Target Telomerase |
| Molecular Formula | C23H23N7O4S |
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| Molecular Weight | 493.542 |