881188-48-3
881188-48-3 structure
- Name: Box5
- Chemical Name: Box5
- CAS Number: 881188-48-3
- Molecular Formula: C25H42N6O11S2
- Molecular Weight: 666.762
- Catalog: Signaling Pathways Stem Cell/Wnt Wnt
- Create Date: 2020-01-11 16:22:49
- Modify Date: 2024-01-02 12:23:09
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Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist; abolishes exogenous Wnt5a stimulation of A2058 cells increased adhesion, migration and invasion, all crucial components of tumor metastasis, also inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.
| Name | Box5 |
|---|
| Description | Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist; abolishes exogenous Wnt5a stimulation of A2058 cells increased adhesion, migration and invasion, all crucial components of tumor metastasis, also inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling. |
|---|---|
| References | References 1. Jenei V, et al. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19473-8. 2. Linnskog R, et al. Oncotarget. 2016 Jun 21;7(25):37790-37802. 3. Yuan S, et al. J Neuroimmune Pharmacol. 2012 Dec;7(4):904-13. 4. Ackers I, et al. Cardiovasc Pathol. 2018 May-Jun;34:1-8. View Related Products by Target Wnt |
| Molecular Formula | C25H42N6O11S2 |
|---|---|
| Molecular Weight | 666.762 |