894554-89-3
894554-89-3 structure
- Name: Deltazinone 1
- Chemical Name: Deltazinone 1
- CAS Number: 894554-89-3
- Molecular Formula: C27H31N5O2
- Molecular Weight: 457.578
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2020-01-12 07:39:51
- Modify Date: 2024-01-06 18:03:30
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Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM; displays excellent selectivity against a broad panel of pharmacologically relevant proteins; inhibits the PDEδ-Ras interaction in in-cell measurement with Kd of 58±17 nM, exhibits less unspecific cytotoxicity than Deltarasin in a set of human pancreatic cancer cell lines, including KRas mutation and oncogenic KRas-dependence, decreases Ras-mediated signalling in pancreatic cancer cells.
| Name | Deltazinone 1 |
|---|
| Description | Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM; displays excellent selectivity against a broad panel of pharmacologically relevant proteins; inhibits the PDEδ-Ras interaction in in-cell measurement with Kd of 58±17 nM, exhibits less unspecific cytotoxicity than Deltarasin in a set of human pancreatic cancer cell lines, including KRas mutation and oncogenic KRas-dependence, decreases Ras-mediated signalling in pancreatic cancer cells. |
|---|---|
| References | References 1. Papke B, et al. Nat Commun. 2016 Apr 20;7:11360. View Related Products by Target Ras |
| Molecular Formula | C27H31N5O2 |
|---|---|
| Molecular Weight | 457.578 |