907166-59-0
907166-59-0 structure
- Name: MI-223
- Chemical Name: MI-223
- CAS Number: 907166-59-0
- Molecular Formula: C23H18ClN3O3
- Molecular Weight: 419.865
- Create Date: 2020-01-19 20:28:56
- Modify Date: 2024-04-11 11:17:54
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MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
| Name | MI-223 |
|---|
| Description | MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib. |
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| References | References 1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516. View Related Products by Target Bcl-2 |
| Molecular Formula | C23H18ClN3O3 |
|---|---|
| Molecular Weight | 419.865 |