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2222635-92-7

2222635-92-7 structure
2222635-92-7 structure
  • Name: MI-389
  • Chemical Name: MI-389
  • CAS Number: 2222635-92-7
  • Molecular Formula: C35H35FN6O6
  • Molecular Weight: 654.69
  • Create Date: 2022-05-30 13:36:53
  • Modify Date: 2024-01-10 11:11:11
  • MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase[1].
Name MI-389
Description MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase[1].
Related Catalog
Target

Cereblon

References

[1]. Ishoey M, et al. Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders. ACS Chem Biol. 2018;13(3):553-560.

Molecular Formula C35H35FN6O6
Molecular Weight 654.69
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title: CAS No. 2222635-92-7 | Chemsrc address: https://m.chemsrc.com/en/baike/1705435.html

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