943344-76-1
943344-76-1 structure
- Name: SR-16157
- Chemical Name: SR-16157
- CAS Number: 943344-76-1
- Molecular Formula: C27H44N2O4S
- Molecular Weight: 492.719
- Create Date: 2020-01-20 13:34:55
- Modify Date: 2025-08-24 20:24:11
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A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM); exerts STS inhibition and antiestrogenic effects, 10 times more potent than the antiestrogens SR-16137 and tamoxifen in cell growth and ERα function test in MCF-7 breast cancer cells; displays profoundly improved ERα binding affinity and antiestrogenic effects on expression of estrogen-regulated genes. Breast Cancer Phase 2 Clinical
| Name | SR-16157 |
|---|
| Description | A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM); exerts STS inhibition and antiestrogenic effects, 10 times more potent than the antiestrogens SR-16137 and tamoxifen in cell growth and ERα function test in MCF-7 breast cancer cells; displays profoundly improved ERα binding affinity and antiestrogenic effects on expression of estrogen-regulated genes. Breast Cancer Phase 2 Clinical |
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| References | References 1. Rasmussen LM, et al. Breast Cancer Res Treat. 2007 Dec;106(2):191-203. 2. Rausch L, et al. Cancer Chemother Pharmacol. 2011 Jun;67(6):1341-52. 3. Wang J, et al. J Pharm Biomed Anal. 2007 Nov 30;45(4):572-82. View Related Products by Target Steroid Sulfatase (STS) Breast Cancer |
| Molecular Formula | C27H44N2O4S |
|---|---|
| Molecular Weight | 492.719 |