SR-16157
Modify Date: 2024-02-01 12:39:53
SR-16157 structure
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Common Name | SR-16157 | ||
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| CAS Number | 943344-76-1 | Molecular Weight | 492.719 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H44N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SR-16157A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM); exerts STS inhibition and antiestrogenic effects, 10 times more potent than the antiestrogens SR-16137 and tamoxifen in cell growth and ERα function test in MCF-7 breast cancer cells; displays profoundly improved ERα binding affinity and antiestrogenic effects on expression of estrogen-regulated genes. Breast Cancer Phase 2 Clinical |
| Name | SR-16157 |
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| Description | A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM); exerts STS inhibition and antiestrogenic effects, 10 times more potent than the antiestrogens SR-16137 and tamoxifen in cell growth and ERα function test in MCF-7 breast cancer cells; displays profoundly improved ERα binding affinity and antiestrogenic effects on expression of estrogen-regulated genes. Breast Cancer Phase 2 Clinical |
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| References | References 1. Rasmussen LM, et al. Breast Cancer Res Treat. 2007 Dec;106(2):191-203. 2. Rausch L, et al. Cancer Chemother Pharmacol. 2011 Jun;67(6):1341-52. 3. Wang J, et al. J Pharm Biomed Anal. 2007 Nov 30;45(4):572-82. View Related Products by Target Steroid Sulfatase (STS) Breast Cancer |
| Molecular Formula | C27H44N2O4S |
|---|---|
| Molecular Weight | 492.719 |