2079892-79-6
2079892-79-6 structure
- Name: RORγt inhibitor 1
- Chemical Name: RORγt inhibitor 1
- CAS Number: 2079892-79-6
- Molecular Formula: C26H33N7O2
- Molecular Weight: 475.597
- Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
- Create Date: 2020-01-13 23:54:08
- Modify Date: 2024-01-14 19:15:32
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A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays; shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ; attenuates expression of genes such as IL26, IL23R and CCR6 in primary human Th17 cells, attenuate the knee swelling response in an antigen-induced arthritis rat models and inhibits IL-17A cytokine production in ex vivo recall assays.
| Name | RORγt inhibitor 1 |
|---|
| Description | A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays; shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ; attenuates expression of genes such as IL26, IL23R and CCR6 in primary human Th17 cells, attenuate the knee swelling response in an antigen-induced arthritis rat models and inhibits IL-17A cytokine production in ex vivo recall assays. |
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| References | References 1. Guendisch U, et al. PLoS One. 2017 Nov 20;12(11):e0188391. 2. Hintermann S, et al. ChemMedChem. 2016 Dec 16;11(24):2640-2648. View Related Products by Target ROR |
| Molecular Formula | C26H33N7O2 |
|---|---|
| Molecular Weight | 475.597 |