RORγt inhibitor 1
Modify Date: 2024-01-14 19:15:32
RORγt inhibitor 1 structure
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Common Name | RORγt inhibitor 1 | ||
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| CAS Number | 2079892-79-6 | Molecular Weight | 475.597 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H33N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RORγt inhibitor 1A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays; shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ; attenuates expression of genes such as IL26, IL23R and CCR6 in primary human Th17 cells, attenuate the knee swelling response in an antigen-induced arthritis rat models and inhibits IL-17A cytokine production in ex vivo recall assays. |
| Name | RORγt inhibitor 1 |
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| Description | A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays; shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ; attenuates expression of genes such as IL26, IL23R and CCR6 in primary human Th17 cells, attenuate the knee swelling response in an antigen-induced arthritis rat models and inhibits IL-17A cytokine production in ex vivo recall assays. |
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| References | References 1. Guendisch U, et al. PLoS One. 2017 Nov 20;12(11):e0188391. 2. Hintermann S, et al. ChemMedChem. 2016 Dec 16;11(24):2640-2648. View Related Products by Target ROR |
| Molecular Formula | C26H33N7O2 |
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| Molecular Weight | 475.597 |