2196245-16-4
2196245-16-4 structure
- Name: Lp-PLA2-IN-3
- Chemical Name: Lp-PLA2-IN-3
- CAS Number: 2196245-16-4
- Molecular Formula: C20H13ClF3N3O3S
- Molecular Weight: 467.85
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
- Create Date: 2020-01-23 13:28:51
- Modify Date: 2024-01-11 13:40:16
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Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2)[1].
| Name | Lp-PLA2-IN-3 |
|---|
| Description | Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2)[1]. |
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| Related Catalog | |
| In Vivo | Lp-PLA2-IN-3 (3 mg/kg; p.o.) treatment shows the Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 3.4 μg h/mL, 7.7 hours and 35.5%, respectively[1]. Lp-PLA2-IN-3 (1 mg/kg; i.v.) treatment shows the CL, Vss, and t1/2 were 3.1mL/min/kg, 0.3 L/kg, 4 hours, respectively[1]. Animal Model: Male Sprague−Dawley (SD) rats (180-220 g)[1] Dosage: 3 mg/kg Administration: p.o. (Pharmacokinetic Analysis) Result: The Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 6.2 μg h/mL, 7.7 hours and 35.5%, respectively. |
| References |
| Molecular Formula | C20H13ClF3N3O3S |
|---|---|
| Molecular Weight | 467.85 |