502887-71-0
502887-71-0 structure
- Name: MMP-9-IN-1
- Chemical Name: MMP-9-IN-1
- CAS Number: 502887-71-0
- Molecular Formula: C16H17F2N3O3S
- Molecular Weight: 369.39
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2020-01-23 23:08:51
- Modify Date: 2024-01-06 15:31:07
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MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs[1].
| Name | MMP-9-IN-1 |
|---|
| Description | MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs[1]. |
|---|---|
| Related Catalog | |
| Target |
MMP-9 |
| In Vitro | MMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity[1]. MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells[1]. Cell Cytotoxicity Assay[1] Cell Line: COS-1 monkey epithelial cell lines Concentration: 100 μM Incubation Time: 24 hours Result: Treatment did not cause notable cytotoxicity. Cell Proliferation Assay[1] Cell Line: HT-1080 and MDA-MB-435 cancer cells expressing endogenous MMP-9 Concentration: 10 μM Incubation Time: 9 days Result: Significant inhibition of cell proliferation. |
| In Vivo | MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor[1]. MMP-9-IN-1 inhibits cancer cell metastasis in vivo[1]. Animal Model: 4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor[1] Dosage: 20 mg/kg Administration: Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks, Result: Resulted in a profound delay in tumor growth. Inhibited cancer cell metastasis. |
| References |
| Molecular Formula | C16H17F2N3O3S |
|---|---|
| Molecular Weight | 369.39 |